The second part of the 25th amendment deals specifically with procedures for a President who is unfit to serve. It has been used three times, all related to colon issues and two of the three were a result of Presidential colonoscopies. – WTF Fun Facts
Source: https://www.businessinsider.com/25th-amendment-colon-trump-reagan-bush-unfit-president-2017-10?r=US&IR=T
