WTF Fun Fact 13377 – Tu Youyou and the Nobel Prize

Tu Youyou is a Chinese scientist and pharmaceutical chemist whose groundbreaking work in the discovery of artemisinin revolutionized malaria treatment. Her contributions have had a significant impact on global health, saving countless lives. Interestingly, she sought (and found) the award-winning compound in the corpus of Ancient Chinese Medicine.

According to the Nobel Prize website (cited below): “She is the first mainland Chinese scientist to have received a Nobel Prize in a scientific category, and she did so without a doctorate, a medical degree, or training abroad.”

The training of Tu Youyou

Born in Ningbo, Zhejiang, China, Tu’s interest in medicine may have started after she had to miss two years of school after a bout of tuberculosis.

Tu’s interests eventually landed her at Beijing Medical College. There, she studied pharmacology – a modern science – but with a traditional backbone. At college, she learned how to classify medicinal plants and extract their active ingredients in order to learn more about their chemical structure. She would do this with many of the thousands of plants in the ancient Chinese medical handbooks.

Tu Youyou went to work at the Academy of Traditional Chinese Medicine in 1955, after graduation.

She was first asked by the Chinese government to help find a treatment for malaria during the Vietnam War. Vietnamese soldiers were dying in droves because the disease had become resistant to the standard treatment – chloroquine. But this posed a global health threat. She joined the battle against the disease after Chairman Mao Zedong launched a project called Project 523 in 1967.

Discovering a new malaria treatment

In 1969, Tu became the head of Project 523 and traveled to Hainan Island in southern China. She had to leave her two young children behind for three years to study the disease in its deadly habitat.

After she returned, the scientific work began.

In Beijing, Tu and her team were facing a difficult situation. Over 240,000 compounds had already been tested for their potential use in anti-malarial drugs, but none worked. That’s when they returned to the ancient Chinese medical text.

A reference to sweet wormwood (known as Artemisia annua) would turn out to be the key. She had identified it for its ability to help with “intermittent fevers” – a key symptom of malaria. It had been used in China around 400 AD.

Turning nature into medicine

Through meticulous experimentation, Tu Youyou and her team successfully isolated a compound from Artemisia annua that demonstrated potent anti-malarial properties. She named this compound artemisinin. It was very successful in killing malaria in laboratory tests.

After lab tests came clinical trials, which were also successful. The great thing about artemisinin was that it helped kill malaria while minimizing the development of resistance to the medication. Artemisinin-based combination therapies (ACTs), which combine artemisinin derivatives with other anti-malarial drugs, have since become the gold standard in malaria treatment worldwide.

Tu Youyou’s groundbreaking discoveries earned her numerous accolades and recognition. In 2015, she was awarded the Nobel Prize in Physiology or Medicine, becoming the first Chinese scientist to receive this prestigious honor. Her contributions have had a profound impact on global health, particularly in regions heavily burdened by malaria.

Tu Youyou’s impact on the future

Artemisinin and its derivatives have transformed malaria treatment and played a crucial role in reducing the mortality rate of this deadly disease. Their widespread use has significantly contributed to the decline in malaria-related deaths worldwide. Tu Youyou’s work continues to inspire scientists, researchers, and healthcare professionals in the ongoing fight against malaria.

Despite the remarkable success of artemisinin-based therapies, challenges remain in the battle against malaria. The emergence of drug resistance, particularly in Southeast Asia, underscores the need for ongoing research and innovative approaches to combat this persistent global health issue. Scientists continue to study artemisinin and explore novel drug combinations to stay ahead of the evolving malaria parasite.

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Source: Tu Youyou – The Nobel Prize website

WTF Fun Fact 12550 – Magical Gladiator Blood

It’s not hard to find references to the drinking of gladiator blood in ancient sources. However, it was most often used to treat what ancient medical writers called “The Sacred Disease,” which we now believe is epilepsy. Some thought it was brought on by the gods, while others argued for a more natural cause.

Of course, there’s no truth to the claim, but epilepsy held an important place in ancient medicine because it stumped doctors for centuries. It could come on suddenly, making it even more mysterious.

And when diseases are misunderstood, their potential cures are likely to get pretty interesting.

In their 2003 article, “Between horror and hope: gladiator’s blood as a cure for epileptics in ancient medicine,” scholars Ferdinand Peter Moog and Axel Karenberg state that not only was gladiator blood a potential cure for this disease but a gladiator’s liver would be consumed as well. AND that the tradition may have continued in some places up into recent times!

“Between the first and the sixth century a single theological and several medical authors reported on the consumption of gladiator’s blood or liver to cure epileptics…
…the magical use of gladiators’ blood continued for centuries. After the prohibition of gladiatorial combat in about 400 AD, an executed individual (particularly had he been beheaded) became the “legitimate” successor to the gladiator.
Occasional indications in early modern textbooks on medicine as well as reports in the popular literature of the 19th and early 20th century document the existence of this ancient magical practice until modern times. Spontaneous recovery of some forms of epilepsy may be responsible for the illusion of therapeutic effectiveness and for the confirming statements by physicians who have commented on this cure.”

As the authors state, the condition we now know as epilepsy got better on its own in some people. But if they had the “gladiator treatment” and did get better, it simply strengthened doctors’ resolve to keep using it.

But why gladiator blood? According to Dr. Lydia Kang, MD, author of the book, Quackery: A Brief History of the Worst Ways to Cure Everything:

“They stemmed from this magical idea that young, healthy males had energy. If you could harness that energy right at the point of death, you could ingest some of this healthfulness. In other words: you are what you eat.” –  WTF fun fact

Source: “Gladiator Blood and Liquid Gold: Good for What Ails You?” — MedPage Today