WTF Fun Fact 13663 – Dog Longevity Drug

For dog lovers, the prospect of a dog longevity drug sounds fantastic. Who doesn’t want their furry friends to live longer, healthier lives?

Recent developments from a San Francisco-based biotech company, Loyal, bring this dream closer to reality. They’ve announced an anti-aging drug for dogs that has cleared its first hurdle for FDA approval. This marks a pivotal moment in veterinary medicine, as it’s the first time the FDA has shown openness to endorsing longevity drugs for pets.

Dog Longevity Drug Holds Promise of Longer Lives for Man’s Best Friend

Loyal’s groundbreaking drug, LOY-001, targets a growth and metabolism hormone called IGF-1. This hormone, linked with size, appears in higher levels in larger dogs and lower in smaller ones. Studies on other species suggest inhibiting IGF-1 can increase lifespans. LOY-001 is aimed at healthy dogs over seven years old and weighing more than 40 pounds. Administered every three to six months by a vet, it holds the potential to slow down the aging process in dogs.

Parallel to this, Loyal is developing LOY-003, a daily pill form of the treatment. CEO Celine Halioua emphasizes that they’re not creating immortal dogs. The goal is to slow their rate of aging, thus maintaining a healthier state for a longer period.

As promising as these developments are, they raise significant ethical questions, particularly concerning the quality of extended life for these animals. Veterinarian Kate Creevy, involved in a similar trial for an anti-aging drug called rapamycin, stresses the importance of ensuring that any extended lifespan is accompanied by good health and quality of life.

Moreover, the human manipulation of dogs through selective breeding, which may have contributed to accelerated aging in larger breeds, underlines the ethical complexities in altering canine aging processes.

Trials and the Future of Canine Health

Loyal plans to start a large clinical trial for LOY-001 with around 1,000 large and giant dogs by either 2024 or 2025. The ultimate aim is to have a market-ready product by 2026. This trial not only represents a major step in veterinary medicine but also opens doors to understanding aging in more complex organisms like humans.

The success of Loyal’s drug could potentially revolutionize how we approach canine health and aging. It offers a glimpse into a future where our canine companions can enjoy longer, healthier lives alongside us. However, it’s crucial to balance this scientific advancement with ethical considerations to ensure the well-being of these beloved animals.

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Source: “A New Drug That Could Extend Dogs’ Lives Inches Closer to Approval” — Smithsonian Magazine

WTF Fun Fact 13662 – What Shapes Our Worldview

Conventional wisdom often suggests that what shapes our worldview is significantly impacted by our background. Specifically, it’s a common assumption that privilege, encompassing factors like socioeconomic status, health, and safety, heavily influences one’s perspective of the world.

However, recent research from the University of Pennsylvania challenges this notion, revealing surprising insights about the relationship between privilege and a positive worldview.

Unraveling Assumptions about What Shapes Our Worldview

This intriguing study, conducted by The Primals Project at Penn’s Positive Psychology Center, looked into primal world beliefs (or “primals”). Primals are fundamental beliefs about the world, such as viewing it as progressing or declining, harmless or threatening, interesting or boring.

Contrary to expectations, the study found that positive primals were not strong indicators of a privileged background.

Methodology and Results

Researchers surveyed over 14,000 individuals, examining their agreement with statements like “Life overflows with opportunity and abundance” and “The world is going downhill.” They also asked laypeople and psychology researchers to predict how different groups would respond based on their socioeconomic status, neighborhood safety, and other factors.

The predicted correlation between privilege and positive worldviews was significantly higher than the actual survey results. This disconnect suggests that positive worldviews may not be as closely tied to privilege as previously thought.

Shifting Perspectives on Trauma and Privilege

The study’s findings indicate that experiencing hardship or adversity doesn’t necessarily result in a negative view of the world.

For example, patients with cystic fibrosis showed a slightly more positive worldview compared to controls. This counters the narrative that those facing significant challenges are destined to view the world negatively.

Interestingly, the study found that women were slightly more likely to view the world as safe, defying the conventional assumption that women perceive the world as more dangerous due to societal and safety concerns.

The University of Pennsylvania’s study opens up new avenues for research. Teams are exploring genetic components and other factors that might influence one’s primal beliefs. With numerous independent research efforts underway, there’s a growing interest in understanding the origins and impacts of these fundamental worldviews.

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Source: “A positive worldview is less associated with privilege than expected” — ScienceDaily

WTF Fun Fact 13661 – Faith and Risk Taking

A recent study from York University’s Faculty of Health reveals an intriguing link between faith and risk-taking. The research, led by Assistant Professor Cindel White, looked into how beliefs about a protective God influence Christians’ willingness to take risks.

The study, published in the Journal of Experimental Social Psychology, suggests that the belief in a benevolent deity can boost confidence in pursuing uncertain or potentially dangerous activities.

Findings About Faith and Risk Taking

White, along with collaborators Chloe Dean and Kristin Laurin from The University of British Columbia, focused on Christian Americans known for their belief in a protective God. The study avoided risks with moral connotations, like drug use, and instead examined ‘morally neutral’ risks.

These included recreational activities like mountain climbing and life decisions such as relocating for a job. The research revealed a reliable connection between these beliefs and an increased willingness to take such risks.

The findings do not necessarily suggest that religious individuals are more inclined to take risks than non-religious people. However, they highlight the role of religious beliefs in creating a sense of safety and positivity. Belief in a protective God appears to help believers cope with life’s uncertainties and stressors. This sense of security and positive outlook may encourage them to seize opportunities they might otherwise avoid.

Understanding the Psychological Safety Net

The study provides insights into how religious beliefs function as coping mechanisms. For many believers, the idea of a protective God offers a psychological safety net.

This belief may empower them to face challenges and uncertainties with more confidence. It’s not just about risk-taking; it’s about how faith shapes the approach to life’s varied situations.

The research has significant implications for understanding the decision-making process of religious individuals. It suggests that their faith could subtly influence choices in everyday life, from career moves to leisure activities.

This understanding could be crucial for psychologists, counselors, and even employers in recognizing the factors that drive the actions and choices of religious individuals.

Broader Perspective on Religious Beliefs

These findings open up a broader perspective on the role of religious beliefs in modern society. They shed light on the nuanced ways faith intersects with daily life, influencing not just moral decisions but also personal and professional risks.

As society becomes increasingly aware of diverse belief systems, such insights are vital for fostering understanding and respect across different cultural and religious backgrounds.

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Source: “Thinking about God inspires risk-taking for believers, study finds” — ScienceDaily

WTF Fun Fact 13660 – Blue Light and Sleep

Scientists have made some interesting discoveries about the connection between blue light and sleep.

Artificial lighting, particularly blue light from LED devices, has a notable impact on us. It disrupts melatonin production, the hormone responsible for regulating sleep, leading to potential sleep issues. But not all blue light is equal.

Blue Light and Sleep

LED lights in our gadgets and homes emit blue light, which ranges in wavelength from 380 to 500 nanometers (nm). However, not all blue light has the same effect. Wavelengths between 460 and 500 nm are particularly disruptive to melatonin production, impacting our ability to fall asleep.

In response to these challenges, researchers have developed innovative “human-centric” LEDs. These lights are designed to support natural circadian rhythms regardless of the time of day they are used.

The researchers created two types of LEDs, each emitting different wavelengths of blue light. One is tailored for daytime use, emitting blue light close to 475 nm, while the other, intended for evening use, emits blue light near 450 nm. This latter wavelength is outside the range known to disturb sleep.

Testing the New LEDs

The research team integrated these LEDs into conventional light bulbs, converting some blue light into red and green with phosphors, to produce white light. They then conducted an experiment in a windowless room, furnished with a desk, treadmill, and bed, equipped with these innovative bulbs.

Over a three-day period, male volunteers stayed in the room, exposed to different lighting conditions controlled by a computer. This setup allowed for a direct comparison between conventional and new LED bulbs.

Saliva samples collected from 22 volunteers revealed significant differences in melatonin levels based on the type of LED exposure. The use of the new LEDs resulted in a 12.2% increase in nighttime melatonin levels and a 21.9% decrease in daytime melatonin compared to exposure to conventional LEDs.

This suggests that the innovative LEDs could promote alertness during the day and enhance relaxation and sleep quality at night.

Towards a Brighter Future with Blue Light

This groundbreaking research has the potential to revolutionize the way we use artificial lighting. By aligning our indoor lighting with our natural circadian rhythms, we could improve overall well-being, work efficiency, and sleep quality. The hope is that manufacturers of LED lamps and electronic displays will implement these findings, creating environments that nurture our natural sleep-wake cycles. As we continue to spend significant time indoors, these advancements in lighting technology could be key to maintaining our health and productivity in the digital age.

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Source: “This next generation blue light could potentially promote or hinder sleep on command” — ScienceDaily

WTF Fun Fact 13656 – Francis Ford Coppola’s Wine

Francis Ford Coppola’s wine is his real source of wealth.

Renowned for his cinematic masterpieces like “The Godfather” and “Apocalypse Now,” embarked on a journey into the wine industry in the 1970s. This venture was not a mere flight of fancy but a passionate pursuit that paralleled his illustrious filmmaking career.

Coppola’s winemaking venture, which began as a modest family tradition, evolved into a significant business enterprise.

The Rise of Coppola’s Wine Empire

In the 1990s, Coppola’s wineries gained traction, overshadowing his work in Hollywood. His dedication to the craft led to an eight-year hiatus from directing.

Remarkably, his return to the director’s chair was funded not by Hollywood studios but by the profits from his thriving wine business. This intersection of art and entrepreneurship highlights Coppola’s versatility and business acumen.

Coppola’s focus on quality and luxury is evident at his Rubicon Estate. He invests in the estate’s continual improvement, planting new vines for the prestigious Rubicon wines, which command prices above $100 per bottle.

This commitment to excellence stems from Coppola’s aspiration for Rubicon to be synonymous with “great” wines, a step above the very good wines produced by other Napa Valley vintners.

A Family Tradition Turned Business

Coppola’s foray into winemaking was rooted in family tradition, stemming from his family’s home winemaking during Prohibition. What started as a fun, personal project gradually transformed into a serious business endeavor. When neighbors expressed interest in his grapes, Coppola saw an opportunity to create something special and seized it.

Coppola’s wine portfolio is diverse, offering both high-end and affordable options. His lower-priced “Francis Ford Coppola Presents” line features brands like Rosso & Bianco and Director’s Cut, with bottles priced between $10 and $27. These wines, made with grapes from various vineyards, are accessible to a wide audience across the U.S.

In contrast, the Rubicon Estate produces wines in the $40 to $125 range, exclusively from organically certified grapes. This attention to quality and sustainability marks Coppola’s commitment to excellence in winemaking.

Coppola’s dedication has earned him respect in the wine industry. Insiders recognize him as a serious vintner, not just a Hollywood celebrity dabbling in wine. He employs top talent in Napa Valley and holds a significant presence in Sonoma County. His passion for high-quality wines and a well-thought-out business plan have garnered industry accolades.

Wine Spectator’s Acknowledgment

Coppola’s wines are poised to appear on Wine Spectator magazine’s list of best-selling U.S. wines. This recognition reflects the brand’s growing popularity and success. Industry experts like Frank Walters and Peter Marks acknowledge Coppola’s influence and the potential for even further refinement and success in the future.

Coppola’s journey in the realms of winemaking and filmmaking exemplifies how passion can drive success in diverse fields. His ability to weave his artistic vision into both cinema and viticulture showcases a rare blend of creativity and business savvy.

Coppola’s use of wine profits to finance his films is a testament to his entrepreneurial spirit. This unique funding approach allowed him to maintain creative control over his projects, free from the constraints of traditional Hollywood financing.

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Source: “Francis Ford Coppola’s big “action” is in wine” — Reuters

WTF Fun Fact 13655 – Ice Age Fire Art

Surviving the Ice Age required more than just hunting and gathering – there was fire art. OK, hear us out.

As they gathered around fires for warmth and safety, something more than just physical comfort emerged. This was a time for them to indulge in an artistic pursuit that continues to fascinate us today.

The Paleolithic Animator and Ice Age Fire Art

In recent research published in PLOS ONE, a team led by archaeologist Andy Needham proposed an intriguing idea. They suggested that Ice Age artists used the flickering light of fire to bring their stone carvings to life.

These 15,000-year-old limestone plaquettes, adorned with animal figures, were not just static art. Instead, under the dynamic light of a fire, they appeared to move, animating the etched creatures. Fire art!

Needham’s team studied various limestone plaquettes found at the Montastruc rock shelter in southern France. These carvings, attributed to the Magdalenian culture, showcased a range of animals like horses, ibex, and reindeer.

Interestingly, these plaquettes showed signs of thermal damage, suggesting exposure to fire. But was this intentional?

Experimental Archaeology Sheds Light

To answer this, the researchers turned to experimental archaeology. They created replica plaquettes and subjected them to different fire scenarios. These experiments aimed to replicate the pinkish discoloration seen on the originals. The results? The patterns suggested that the artworks were deliberately placed near the hearth, likely as part of the creative process.

Further exploring this idea, the team used virtual reality to simulate firelight’s effect on the plaquettes. The results were fascinating. The irregular lighting from the fire brought an illusion of movement, making the animals seem like they were alive and moving across the stone surface.

The Role of Pareidolia in Ice Age Fire Art

This phenomenon can be partly explained by pareidolia, where the human brain perceives familiar patterns in random objects. In the flickering firelight, viewers would see incomplete forms on the plaquettes. Their brains would fill in the gaps, creating a dynamic viewing experience.

The Ice Age artists might have used this to their advantage. They could start with natural rock features to shape their animals, allowing the firelight to complete the picture. This interaction between the art, the rock’s natural form, and the dynamic firelight created a captivating experience, unique to the Paleolithic era.

Beyond survival, these artistic endeavors provided a social outlet. After a day of survival tasks, our ancestors likely gathered around the fire, not just for warmth but for a communal experience. Here, they could indulge in storytelling, companionship, and artistic expression.

The act of creating art by firelight was perhaps as important as the art itself. It wasn’t just about the final product but about the process of creation, the gathering of minds, and the sharing of ideas. This communal aspect of Ice Age art adds a deeply human dimension to our understanding of these ancient peoples.

Art as a Cultural Practice

Ice Age art wasn’t merely aesthetic; it was a cultural practice imbued with meaning. The process of drawing, the summoning of spirits, and even acts of destruction (like deliberate breakage or fire damage) could have had significant roles in their society.

These artistic sessions by the firelight might have served multiple purposes – from summoning spirits to strengthening community bonds. The plaquettes, once used, could have been discarded or intentionally destroyed, suggesting a transient nature to this art form.

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Source: “Ice Age Artists May Have Used Firelight to Animate Carvings” — Smithsonian Magazine

WTF Fun Fact 13653 – Vomitoriums

The ancient vomitoriums apparently had nothing to do with vomiting at all!

The “vomitorium” has long been associated with images of ancient Romans indulging in excessive feasting only to purge themselves to eat more. However, this widespread belief is a historical misconception. The real meaning of vomitorium in Roman culture was quite different and far less grotesque.

Vomitorium are Exits

In reality, a vomitorium was an architectural feature in ancient Roman amphitheaters and stadiums. The word, derived from the Latin vomitus, which means to spew forth, referred to the large passageways that allowed crowds to exit rapidly into the streets.

These passageways were efficient in dispersing large groups of people from the venues, similar to how food is expelled from the stomach.

The false notion of the vomitorium as a place for purging after excessive eating likely stemmed from a misunderstanding of the Latin language.

It was an easy jump from “vomitorium,” a term describing the spewing of crowds, to a place for vomiting. The misinterpretation was possibly fueled by modern literature and an already existing stereotype of ancient Romans as excessively indulgent.

Literary Exaggerations

Classical texts that described Roman feasts and excesses played a role in cementing this myth. Works like Seneca’s Letters and the satirical ‘Satyricon’ by Petronius depicted scenes of lavish Roman feasts and debauchery. These descriptions, often satirical and exaggerated, influenced modern interpretations and led to the vomitorium myth.

Roman feasts, especially among the upper class, were indeed grand. They involved elaborate dishes and communal eating. Entertainment was common, with dancers and musicians adding to the festivities. Women and men dined together, which was a departure from the Greek tradition.

The feasts could include extravagant presentations, but there is no historical evidence to suggest that these gatherings included rooms specifically designated for purging.

Contrary to the image of constant overindulgence, the diets of both wealthy and poorer Romans were predominantly grain-based. The wealthy had more access to wheat and meats, while the poorer sections of society consumed more millet.

This dietary pattern indicates that while the rich could afford more lavish meals, their eating habits were not as extreme as the myth of the vomitorium would suggest.

Debunking the Myth of Vomitoriums

The vomitorium is a great example of how misconceptions can arise from misinterpretations and satirical representations. It wasn’t a space for bingeing and purging but rather an architectural innovation for crowd management.

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Source: “Purging the Myth of the Vomitorium” — Scientific American

WTF Fun Fact 13550 – The Cincinnati Redlegs

In the early 1950s, the Cincinnati Reds became the Cincinnati Redlegs after the team found their name entangled in the political tensions of the era.

As America’s fear of communism grew, particularly during the Korean War, the Reds decided to change their name to the Cincinnati Redlegs between 1953 and 1959. This decision wasn’t about sports; it was a move to distance the team from any communist associations, a concern amplified by the rise of McCarthyism.

Historical Roots and Political Pressures

The original name, the Cincinnati Red Stockings, dates back to 1869, becoming the Reds in 1881. However, the post-World War II era marked a period of heightened suspicion towards communism, often referred to as “The Red Scare.”

Senator Joseph McCarthy’s public witch hunts for communist sympathizers cast a shadow of fear across America. The term “Reds” became uncomfortably close to “Reds,” a common term for communists.

To avoid unwanted connections, the team opted for “Redlegs,” a nod to its historical roots and a safe distance from political controversy.

The Cincinnati Redlegs and Uniform Changes

During this period, some of the team’s most celebrated players, including Frank Robinson and Joe Nuxhall, played under the Redlegs banner. Despite the official name change, the team’s jerseys still sported the word “Reds,” and fans and media often continued to refer to them by their original name.

In 1956, an attempt to further avoid the “Reds” association led to jersey modifications, including a season featuring a Mr. Redlegs logo. However, these changes were short-lived.

Senator McCarthy’s influence dwindled following his senate censure in 1954 and his subsequent death in 1957. With the decline of McCarthyism, the climate of fear surrounding communism receded. By 1959, the team reclaimed its original name, the Cincinnati Reds.

The word “Reds” reappeared on their uniforms in 1961, a year marking their return to the postseason as National League pennant winners. Interestingly, the team experienced limited success as the Redlegs, with only two winning seasons during this period.

Reflections on the Reds’ Name Change

The story of the Reds becoming the Redlegs is a fascinating example of how sports can intersect with politics. It reflects a time when fear and suspicion influenced various aspects of American life, including the world of baseball. The Reds’ decision to change their name was a response to the prevailing political climate, a move to safeguard the team’s image amid national paranoia.

While the Redlegs name was relatively short-lived, it remains an interesting chapter in the team’s history. It signifies how external factors can impact sports teams and their identities. The era also reminds us of the power of names and symbols in representing and reflecting societal values and concerns.

Today, the Cincinnati Reds are firmly established with their original name, with the “Redlegs” period serving as a historical footnote. The team continues to build upon its rich history, contributing to the dynamic world of baseball while staying clear of political controversies that once led to a significant, if temporary, identity change.

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Source: “How the Reds became the Redlegs” — MLB.com

WTF Fun Fact 13648 – The Greek Gymnazein

The term ‘gymnastics’ comes from the Greek gymnazein, which means “to exercise naked.” This ancient practice, initially a method of training young men for warfare, has significantly evolved over the millennia.

Today, it’s a sophisticated sport with precise routines and complex scoring systems. Let’s delve into how gymnastics transformed from its ancient roots to the contemporary spectacle we see today.

The Greek Gymnazein and Naked Training

Gymnastics has its roots in ancient civilizations. Egyptian hieroglyphs and Chinese engravings show that gymnastics-like activities were common in these cultures. The Greeks, however, are credited with developing gymnastics as a method to prepare young men for battle. Originally, these exercises were performed naked – a practice that is unimaginable in today’s times.

As the sport evolved, it moved away from its military training purpose. By the early 19th century, Friedrich Ludwig Jahn, known as the “father of gymnastics,” founded gymnastics centers across Germany. These centers aimed to foster health and patriotism among the youth. Jahn’s influence extended to developing early versions of apparatuses that are still used in modern gymnastics.

Apparatus Evolution from the Greek Gymnazein

Gymnastics today is divided into different apparatuses, each with its own history and evolution.

  1. Pommel Horse: This apparatus originated as a method for soldiers to practice mounting horses. Jahn developed a more sophisticated version to train the body for strength and agility.
  2. Parallel and Horizontal Bars: Also attributed to Jahn, these apparatuses have evolved significantly. The women’s uneven bars, derived from parallel bars, showcase a combination of agility and grace.
  3. The Vault: This apparatus underwent significant redesign for safety reasons. The modern vaulting table, with its wider and cushioned surface, replaced the older, more dangerous design.
  4. Still Rings: Known for requiring immense strength, the still rings date back thousands of years to Italy. They emphasize stability and control, with athletes aiming to keep the rings as stationary as possible.
  5. Balance Beam: What started as a simple log suspended in the air is now a padded beam, requiring extreme focus and precision. It’s an event where the slightest error can have significant consequences.

The modern Gymnazein

Modern gymnastics is far more than just physical exercise; it’s a blend of art, grace, strength, and agility. It demands not only physical prowess but also mental focus and artistic expression. Each routine, whether on the floor or an apparatus, tells a story, and gymnasts spend countless hours perfecting every movement and expression.

The Olympics have been a major stage for gymnastics since its inclusion in the modern games. It’s here that gymnastics truly comes into the limelight, with athletes from around the world showcasing their skills. The evolution of the sport is evident in the level of difficulty and creativity displayed in these routines, pushing the boundaries of what was thought possible in Jahn’s time.

Gymnastics is not just for elite athletes. It’s a sport that offers something for everyone, from young children learning coordination and balance to adults looking for a fun way to stay fit. It helps develop a range of physical skills like strength, flexibility, and coordination, as well as mental skills like concentration and discipline.

The Future of Gymnastics

The future of gymnastics looks promising, with new techniques and elements being introduced regularly. Advances in coaching, equipment, and athlete training continue to elevate the sport to new heights. The emphasis on safety, combined with a push for more artistic expression, ensures that gymnastics will remain a beloved and exciting sport for generations to come.

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