WTF Fun Fact 13574 – Katalin Karikó

Katalin Karikó’s journey to Nobel glory is one of resilience and steadfast dedication. A biochemist, Karikó had always been keen on exploring the therapeutic potentials of mRNA.

She obtained her PhD from Hungary’s esteemed Szeged University in 1982 and secured a tenure-track professor position at the University of Pennsylvania in 1989. But her research into RNA faced numerous challenges.

Funding eluded her, and her experiments saw little success. The 1990s brought more trials. This included a cancer diagnosis, the choice to abandon her research or accept a demotion, and a pay cut. She chose the latter, demonstrating her unyielding commitment to mRNA’s potential.

Katalin Karikó”s Partnership with Weissman

1997 marked a turning point. Immunologist Drew Weissman joined the University of Pennsylvania and partnered with Karikó. His interest lay in developing an HIV vaccine. The goal was to prime immune responses with dendritic cells, known for training T cells against foreign antigens. Their collaboration led to the discovery that synthetic, unmodified mRNA provoked dendritic cells into activating inflammatory responses.

The duo’s realization that mammalian cell RNA was frequently chemically modified (while bacterial DNA and RNA often weren’t) changed the course of their research. Another significant insight was that toll-like receptors (TLRs) specifically detected DNA and RNA modifications to trigger inflammation. Their 2005 research paper unveiled that synthetic RNA activated several TLRs, causing inflammatory responses. But adding specific modifications to the synthetic mRNA’s bases curtailed these responses and even enhanced protein production.

mRNA Shaping Modern Vaccine Production

This groundbreaking work ushered in the era of mRNA therapeutics. It catalyzed the inception of Moderna and BioNTech, the companies that later formulated the lifesaving mRNA COVID-19 vaccines. A testament to Karikó and Weissman’s work is the modified base m1 Ψ, now integral to Moderna and Pfizer-BioNTech’s vaccine production.

Recognition Overlooked Despite the promise and subsequent success of her research, Karikó’s contributions remained largely overshadowed. The scientific community’s initial apathy was evident: post their 2005 revelation, Karikó revealed a lack of interest from peers and major biopharma companies. By 2013, this disregard culminated in her departure from the University of Pennsylvania. Yet, adversity wasn’t new to her. Rather than be deterred, she associated with BioNTech, ascending from hands-on benchwork to senior vice presidency. In 2021, she returned to academia, serving at Szeged University and as adjunct faculty at UPenn. Meanwhile, Weissman continued at UPenn, helming the Penn Institute for RNA Innovations.

Katalin Karikó and Nobel Acclaim

The Nobel Prize in Physiology or Medicine awarded to Karikó and Weissman celebrates their persistent, pioneering work on mRNA technology. This research directly paved the way for the creation of the frontrunner COVID-19 vaccines. It’s a fitting tribute to Karikó, who faced professional setbacks and health challenges, yet never deviated from her belief in mRNA’s potential. For her, the Nobel isn’t just an award—it’s validation of decades of unwavering commitment.

The story of Katalin Karikó story serves as an inspiring lesson on perseverance. Her Nobel win, alongside Drew Weissman, underscores the importance of dedication to scientific exploration, even in the face of skepticism and adversity. Their work expanded our understanding of mRNA and provided the foundation for life-saving vaccines during a global pandemic.

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Source: “After being demoted and forced to retire, mRNA researcher wins Nobel” — Ars Technica

WTF Fun Fact 13572 – Reproduction in Space

SpaceBorn United, a Netherlands-based startup, is rocketing into the next frontier of space exploration: human reproduction in space.

While recent advancements have made space travel more tangible, the challenge of ensuring human reproduction in foreign environments remains largely unaddressed. Natural conception in space poses multiple risks. Factors such as space radiation and potential changes in embryonic development in microgravity environments call for an innovative approach.

IVF: The Compact Solution

To meet this challenge head-on, SpaceBorn United has pioneered the development of a miniaturized in-vitro fertilization (IVF) and embryo incubator. This device, resembling a CD-ROM in size, uses advanced microfluidic technologies to condense the extensive apparatus required for IVF. The disc, beyond being programmable, spins to simulate the effects of Earth-like gravity, hosting distinct chambers for sperm fluids and female eggs, enabling a controlled conception process.

SpaceBorn’s initiative not only targets the mysteries of space reproduction but also aims to enhance IVF treatments on Earth. Conducting IVF in space’s varying gravity levels might yield insights, potentially refining IVF procedures on our home planet.

Regulatory and Ethical Hurdles

The path SpaceBorn United treads is strewn with challenges. International guidelines tightly regulate human embryo research. These standards, which limit the cultivation of human embryos to a mere 14 days, present a formidable obstacle for the company. Their planned ARTIS missions, set to embark into space in the forthcoming years, will initially involve mouse cells. Transitioning to human cells hinges on both successful results and regulatory approvals.

The Future of Space Reproduction

Despite the intricacies involved, SpaceBorn United’s ambition transcends mere conception in space. Should embryos gain the required approvals, they envision the subsequent stages of pregnancy and birth taking place on Earth, ensuring safety and optimal conditions.

The recent surge in the space tourism industry, backed by heavy investments, paints a future where common individuals, not just astronauts, venture into space or even other planets. Yet, amid these grand visions, the elemental aspect of long-term human survival and propagation in alien environments is often overlooked. SpaceBorn United’s mission accentuates this crucial element, reminding the world that space exploration is not solely about setting foot on new territories but ensuring life flourishes there.

As space exploration narratives continue to captivate global attention, initiatives like SpaceBorn United’s push the boundaries of what’s possible. Their work underscores the holistic challenges of becoming an interplanetary species, spotlighting the importance of life itself in the vastness of space.

 WTF fun facts

Source: “STARTUP PLANNING TO LAUNCH IVF AND EMBRYO INCUBATOR INTO SPACE” — Futurism

WTF Fun Fact 13568 – Smoking Math

Smoking math? No, it’s not a typo. Researchers at Ohio State University found a surprising correlation during a research study in 2020. Smokers with better math skills are more inclined to quit smoking.

Crunching the Numbers on Smoking Math

To kick things off, researchers gauged the mathematical abilities of 696 adult smokers using a standardized test. After this assessment, participants encountered eight diverse cigarette warning labels, each paired with risk statistics. For instance, one of the statistics presented was, “75.4 percent of smokers will die before the age of 85, compared to 53.7 percent of non-smokers.”

Brittany Shoots-Reinhard, the study’s lead author, shared a crucial observation: individuals with heightened math skills retained more of the risk statistics. This increased retention directly influenced their perception of smoking dangers and their intentions to quit.

Math, Memory, and Momentum

While all participants saw the same warning labels, memory retention varied. High-emotion labels, like images of diseased lungs, seemed less memorable initially compared to low-emotion ones, such as cartoon gravestones.

However, a follow-up after six weeks revealed the high-emotion warnings stayed more vivid in participants’ minds over time.

The Role of Numeracy in Smoking Math

A pivotal revelation from the data was the role of numeracy. Smokers with higher math abilities remembered smoking-related risks better, which in turn elevated their intentions to quit.

Shoots-Reinhard emphasized the need to re-evaluate how we present risk data to smokers, especially those who may struggle with understanding numerical information. Simplified communication strategies, like infographics, might bridge the comprehension gap for the less numerate.

The Road Ahead

This research shines a spotlight on the importance of effective risk communication. As Shoots-Reinhard asserts, understanding risk equips smokers to make informed decisions. The ultimate aim? To empower more smokers with the knowledge and resolve to quit.

In a nutshell, Ohio State University’s research reveals a profound insight: the road to quitting smoking intertwines not just with understanding health risks but also with one’s ability to comprehend numbers. For many smokers, the motivation to quit might well be a matter of math.

 WTF fun facts

Source: “Smokers good at math are more likely to want to quit” — Science Daily

WTF Fun Fact 13566 – Can You Forget a Language?

Can you forget a language? Can your brain really unlearn it?

If you took a high school Spanish or French class in which you spent the period reciting verbs and learning to ask for directions to the nearest beach, you may have no problem believing that it’s possible to forget an entire language.

But when it comes to our mother tongue, can it truly fade from our minds?

Can You Really “Forget” Your Native Language?

“Language attrition” is the phenomenon in which language proficiency slowly erodes from our brains over time. Professor Monika S. Schmid, a linguistic expert from the University of York, studies this, noting that an individual may experience bouts of hesitation, mix up expressions, or entirely forget specific terms sometimes.

While aging adults may find that certain words or phrases become elusive, they’re unlikely to completely lose grip on a language they once mastered. On the contrary, youngsters might experience a profound shift.

Kids can learn languages more rapidly than adults. But they can also lose it entirely if they aren’t continuously exposed to the language. For instance, a young Russian girl adopted by an American family demonstrated a rapid decline in her Russian vocabulary as she embraced English words.

The Brain’s Role in Language Retention

A lot revolves around the brain’s architecture. Interestingly, birds and their songs, especially those from the biological order Passeriformes, offer us a clue about retaining language.

These creatures are equipped with a dual-circuit system in their brains, first learning their song and then reproducing it later. A similar framework seems to exist in humans, particularly during early developmental stages.

In essence, by early adolescence, our first language gets imprinted in our brains. While we may overlook certain terms or expressions, the core structure remains intact. This also underscores why many struggle to shed their native accent, even after mastering multiple languages.

But most importantly, it suggests that we can’t entirely unlearn a language.

Avoiding Language Attrition

Contrary to what many might believe, staying connected with speakers of one’s native language isn’t always the antidote to attrition. An intriguing observation among Cuban immigrants in Miami highlighted this. Even while in a predominantly Spanish-speaking environment, they experienced a dilution in their native linguistic structures, largely due to their interaction with diverse Spanish dialects.

But that’s not a loss of language – it’s an evolution. And it’s pivotal to recognize that language change isn’t necessarily negative.

So, Can You Forget a Language?

Witnessing one’s primary language slip away can stir deep emotions, especially when one’s linguistic roots are linked to personal history and identity.

But here’s the silver lining: research continually reinforces the notion that our foundational language remains with us. While accents, dialects, and specific terms may evolve, the foundational structure remains.

So, while languages might fade, shift, or transform, they’re never truly forgotten.

 WTF fun facts

Source: “Can You Unlearn A Language?” — IFL Science

WTF Fun Fact 13565 – A Way To Regrow Teeth?

Many of us grapple with tooth loss after an injury or other dental issue – so wouldn’t it be nice if, instead of paying thousands of dollars for a porcelain replacement, scientists found a way to help us regrow teeth?

Well, we’re getting closer!

Researchers from the University of Plymouth have made groundbreaking progress, unveiling a gene that may hold the secret to tooth regeneration.

The Power of Stem Cells

Historically, stem cells have been the beacon of hope in understanding and treating many diseases. That’s because they hold unparalleled potential by being capable of transforming into almost any cell type the body might need. Whether it’s forming new blood cells or rejuvenating bone cells, stem cells are invaluable in helping us recover and regenerate.

It’s no wonder, then, that scientists often harvest stem cells from youthful sources like primary teeth or wisdom teeth. Simply put, younger cells teem with vitality, making them robust candidates for regenerative medicine.

Stem cell therapy has, over the years, provided relief to patients battling conditions ranging from Alzheimer’s and diabetes to multiple sclerosis.

However, only recently have scientists honed in on how stem cells can revolutionize dental health.

Revolutionary Findings to Help Regrow Teeth

Dr. Bing Hu of the Peninsula Dental School at the University of Plymouth and his global team of scientists have uncovered a game-changing revelation: the Dlk1 gene. This gene seems to be the catalyst for enhanced stem cell activation and tissue renewal.

Their journey began with the discovery of a previously unknown group of stem cells in mouse incisors.

Typically found in muscles and bones, these mesenchymal cells spring into action when exposed to the Dlk1 gene. The result? An increased production of dentin – a crucial component in teeth.

Even more impressive was Dlk1’s ability to regenerate tissues in mice with dental injuries.

Future Implications

Of course, with all major discoveries come the caveats. Dr. Hu emphasizes the importance of further studies to cement their initial findings. Yet, he remains optimistic about transitioning from animal models to human trials soon.

This research is a beacon of hope for those who have struggled financially to have lost teeth replaced. Imagine a future where dental procedures are not only more efficient but also more affordable. A future where losing a tooth doesn’t spell permanent loss, but a temporary inconvenience.

While the Plymouth team’s findings are revolutionary, they aren’t the first to tread this path. Back in 2021, a study from Japan revealed the potential of targeting genes to regrow teeth in animals. Their focus? The USAG-1 gene. Fast forward to today, and this Japanese team is setting the stage for a 2024 clinical trial, targeting tooth regeneration in humans.

If all goes well, by 2030, we might be ushering in a new era of dental care.

 WTF fun facts

Source: “Humans Have a Third Set of Teeth. New Medicine May Help Them Grow” — Popular Mechanics and “Scientists Discover New Gene That Can Help Repair Teeth” — Today’s RDH

WTF Fun Fact 13564 – Parasites Make Zombie Ants

Just what we need – zombie ants. Although, to be fair, this whole brain-controlling parasite thing sounds MUCH worse for the ants.

Nature’s Puppet Show

In Denmark’s Bidstrup Forests, ants unknowingly perform a choreographed dance. It’s orchestrated by a tiny parasite – the lancet liver fluke. This flatworm manipulates ants, driving them to the tip of grass blades and priming them for consumption by grazing animals.

It’s a strategy that ensures the parasite’s survival and researchers from the University of Copenhagen have delved deeper into the nuances of this relationship.

Creating Zombie Ants

One would imagine the parasite drives the ant to the grass top and leaves it there. But nature, as usual, is more complex.

A research team from the University of Copenhagen’s Department of Plant and Environmental Sciences discovered that the fluke intelligently navigates the ant’s actions based on temperature.

In the cool embrace of dawn and dusk, when cattle and deer graze, the infected ants climb to the grass’s pinnacle. But as the sun rises and temperatures soar, the fluke directs its ant host back down the blade, protecting it from the sun’s potentially lethal heat.

In other words, not only do the flukes turn the ants into “zombies,” the process is affected by temperature. The temperature-driven “zombie switch” fascinated the researchers. There was clear evidence that lower temperatures correlated with ants attaching to grass tips.

A Parasitic Mystery

Inside an infected ant, a multitude of liver flukes resides. Yet, only one needs to sacrifice itself to venture to the brain to assume control, altering the ant’s behavior.

This pioneering fluke, after ensuring the ant’s consumption by a grazer, also meets its end in the hostile environment of the grazer’s stomach.

However, the others, safely encased within the ant’s abdomen, are shielded in protective capsules, ensuring their survival and journey into the grazing animal’s liver.

By modifying their host’s behavior, these parasites significantly influence the food chain dynamics, affecting who eats whom in the natural world.

While understanding temperature-dependent control is a significant leap, the precise mechanics remain elusive. What chemical concoction does the liver fluke deploy to zombify the ants? That’s the next puzzle the team aims to solve.

While the concept of “mind control” might seem like science fiction, for the ants in the clutches of the liver fluke, it’s a daily reality.

 WTF fun facts

Source: “Brain-altering parasite turns ants into zombies at dawn and dusk” — ScienceDaily

WTF Fun Fact 13563 – Boosting Math Learning

A study from the Universities of Surrey and Oxford, Loughborough University, and Radboud University in The Netherlands suggests that electrical noise stimulation might be a tool to enhance math learning, especially for those who typically struggle with the subject.

What’s Neurostimulation?

Neurostimulation, a non-invasive technique that involves exciting specific brain regions, has the potential to enhance learning. However, we’ve long been limited in our understanding of the physiological transformations it induces in the brain – and the extent of subsequent learning outcomes.

The researchers aimed to fill this knowledge gap by investigating how electrical noise stimulation, when applied to the frontal part of the brain, might affect mathematical learning.

We’re not sure if that sounds better or worse than just studying harder. (Though this method typically involves applying a small electrical current to the scalp to influence the brain’s neuronal activity, and it doesn’t hurt.)

The Study

The study enlisted 102 participants. Their mathematical prowess was evaluated using a set of multiplication problems. Subsequently, the researchers divided them into four groups:

  1. A learning group exposed to high-frequency random electrical noise stimulation.
  2. An overlearning group that practiced multiplication problems, even beyond mastery, with the same high-frequency stimulation.
  3. Two placebo groups: both a learning and an overlearning group, where participants experienced similar conditions to real stimulation but without significant electrical currents.

Electroencephalogram (EEG) recordings were essential in this study as they provided a window into the brain’s activity both before and after the stimulation.

Stimulating the Brain for Math Learning

The study discovered a fascinating link between brain excitation levels and the impact of electrical noise stimulation.

Specifically, individuals who exhibited lower brain excitation when initially assessed on mathematical problems seemed to benefit from the stimulation by demonstrating improved mathematical abilities.

On the contrary, those with naturally higher brain excitability and those in placebo groups did not show notable improvements after the experiment.

Not everyone’s brain responds in the same way to external stimuli. The research indicated that individuals whose brains were less excited by mathematics before the stimulation showed improvement in mathematical abilities after the electrical noise stimulation. Those with already high levels of excitation did not show the same benefits.

This differential response suggests that the stimulation may have a sort of “ceiling effect” where it’s only effective up to a certain level of natural brain excitability.

The Implications of the Experiment

It may be the case that those with inherently lower brain excitability might be prime candidates for such stimulation, potentially experiencing a jump in learning outcomes. However, individuals with high brain excitability might not find the same benefit.

Professor Roi Cohen Kadosh reflected on the broader significance of the findings. He highlighted the profound nature of learning in human life, from mundane daily tasks like driving to intricate skills like coding. This research, according to him, gives a deeper understanding of the mechanisms and conditions under which neurostimulation could be effective.

The Future of Learning Math

The findings from this study hold the promise of reshaping approaches to learning. By understanding when and how to apply neurostimulation, tailored learning strategies could be developed.

Of course, everyone will form their own opinion about whether tinkering with the brain is worth the outcome.

While this study offers exciting insights, it’s part of an ongoing scientific conversation to see if the results are repeatable.

 WTF fun facts

Source: “Electrical noise stimulation applied to the brain could be key to boosting math learning” — ScienceDaily

WTF Fun Fact 13560 – Overconfidence in Scientific Knowledge

People’s overconfidence in their own scientific knowledge is usually a good sign that they don’t know much. In fact, the more negatively people view science, the more likely they are to be overestimating their scientific knowledge.

A study led by Cristina Fonseca of the Genetics Society and Laurence Hurst of the University of Bath, among other colleagues, recently looked at the intricacies of this phenomenon.

The Perception vs. Reality Gap in Scientific Knowledge

Ever met someone who confidently declared an opinion on a scientific subject only to find that their actual knowledge on the matter was limited? Why do people have varying attitudes towards well-evidenced science?

To unravel this complex relationship between attitude and self-perceived knowledge, over 2,000 UK adults were surveyed. The survey touched on their attitudes towards science and how they gauge their own understanding. Prior studies had indicated that those negative towards science had limited textbook knowledge but high self-belief in their comprehension. Building on this, the team investigated if this high self-belief was a common trait among all strong attitudes.

Focusing specifically on genetic science, the team posed attitudinal questions and queries about individuals’ self-rated understanding of terminologies like DNA. The findings were clear-cut: individuals at both extremes of the attitude spectrum—whether strongly in favor or against science—displayed high self-belief in their own comprehension. Conversely, those with a neutral stance were less confident in their grasp.

The Psychological Implications of Overconfidence

Psychologically, this is a logical pattern. To vehemently hold an opinion, one needs to be profoundly convinced of their understanding of the foundational facts. However, when delving deeper, a clear disparity emerges.

Those with strong negative sentiments, despite their self-belief, lacked extensive textbook knowledge. On the other hand, science proponents not only believed they understood the subject but also performed commendably in factual tests.

Rethinking Science Communication

Traditionally, improving scientific literacy focused on transferring knowledge from experts to the general public. Yet, this method might not always be effective and can sometimes even backfire. This study indicates a more fruitful approach might involve reconciling the gap between actual knowledge and self-perceived understanding.

Professor Anne Ferguson-Smith aptly points out the challenge in this: addressing misconceptions requires dismantling what individuals believe they know about science and instilling a more accurate comprehension.

This revelation implies a re-evaluation of strategies in science communication. Instead of just disseminating facts, there’s a pressing need to address individuals’ self-beliefs and bridge the gap between perception and reality. In doing so, a more informed and receptive audience for science can be fostered.

 WTF fun facts

Source: “It isn’t what you know, it’s what you think you know” — Science Daily

WTF Fun Fact 13558 – Mental Imagery

Teenagers are often vulnerable to spirals of negative thoughts, but new research suggests a possible solution: mental imagery.

The Study on Mental Imagery for Teens

Oregon State’s Hannah Lawrence, an assistant professor of psychology, spearheaded the study. The results indicated that shifting focus to mental imagery acts is a strong distractor. In fact, it’s more of a distraction than simple verbal thoughts for adolescents trapped in negative ruminations.

Lawrence’s insights shine a light on a significant issue. Drowning in past regrets not only deepens one’s sorrow but also makes emotional regulation a greater challenge.

Introducing brief diversions, especially in the form of mental imagery, offers a momentary break from these cyclic patterns. This could potentially facilitate a bridge to more extensive help through therapy, familial support, or friendships.

Experiment Procedure

Published in the Journal of Affective Disorders, the research aimed to contrast the impact of verbal thoughts and imagery-based thoughts on the general mood of adolescent participants.

The study encompassed 145 participants, aged 13 to 17, predominantly white, with 62% females. These individuals were from a rural New England area. A striking 39% displayed symptoms consistent with clinical depression.

The mood-setting phase involved an online game, inducing feelings of exclusion among the participants. Subsequently, they were divided into groups, engaging in either rumination or distraction exercises using either verbal or imagery-based prompts.

For rumination, a prompt might be “Imagine the kind of person you think you should be.” For distraction, it could be as mundane as “Think about your grocery list.”

Key Findings on the Power of Mental Imagery

The research found that both forms of rumination (verbal and imagery) affected the participants’ moods similarly. However, mental imagery stood out as a more potent form of distraction.

Lawrence noted, “Using mental imagery seems to help us improve our affect, as well as regulate our nervous system.” The form of negative thoughts, be it verbal or visual, may not matter as much as the relentless focus on distressing matters.

The potency of mental imagery is still not entirely understood. It may be the case that imagery demands more effort and is more immersive. Therefore, it elicits stronger emotional responses, thus serving as a better distraction.

There’s also evidence suggesting that visualizing mental images activates the same brain regions as witnessing those events firsthand.

The Evolution of Rumination

Lawrence has observed that while some adults stick to one form of rumination, most teenagers report employing both verbal thoughts and mental imagery. These patterns might solidify over time, becoming habitual and reinforcing the negative imagery or messages.

Lawrence highlights the crucial nature of her work with teenagers, expressing her hope that early interventions can help these youngsters navigate to adulthood without being tethered to detrimental thought patterns.

 WTF fun facts

Source: “Mental imagery a helpful way to distract teens from negative thought patterns” — Science Daily