canine

WTF Fun Fact 13663 – Dog Longevity Drug

For dog lovers, the prospect of a dog longevity drug sounds fantastic. Who doesn’t want their furry friends to live longer, healthier lives?

Recent developments from a San Francisco-based biotech company, Loyal, bring this dream closer to reality. They’ve announced an anti-aging drug for dogs that has cleared its first hurdle for FDA approval. This marks a pivotal moment in veterinary medicine, as it’s the first time the FDA has shown openness to endorsing longevity drugs for pets.

Dog Longevity Drug Holds Promise of Longer Lives for Man’s Best Friend

Loyal’s groundbreaking drug, LOY-001, targets a growth and metabolism hormone called IGF-1. This hormone, linked with size, appears in higher levels in larger dogs and lower in smaller ones. Studies on other species suggest inhibiting IGF-1 can increase lifespans. LOY-001 is aimed at healthy dogs over seven years old and weighing more than 40 pounds. Administered every three to six months by a vet, it holds the potential to slow down the aging process in dogs.

Parallel to this, Loyal is developing LOY-003, a daily pill form of the treatment. CEO Celine Halioua emphasizes that they’re not creating immortal dogs. The goal is to slow their rate of aging, thus maintaining a healthier state for a longer period.

As promising as these developments are, they raise significant ethical questions, particularly concerning the quality of extended life for these animals. Veterinarian Kate Creevy, involved in a similar trial for an anti-aging drug called rapamycin, stresses the importance of ensuring that any extended lifespan is accompanied by good health and quality of life.

Moreover, the human manipulation of dogs through selective breeding, which may have contributed to accelerated aging in larger breeds, underlines the ethical complexities in altering canine aging processes.

Trials and the Future of Canine Health

Loyal plans to start a large clinical trial for LOY-001 with around 1,000 large and giant dogs by either 2024 or 2025. The ultimate aim is to have a market-ready product by 2026. This trial not only represents a major step in veterinary medicine but also opens doors to understanding aging in more complex organisms like humans.

The success of Loyal’s drug could potentially revolutionize how we approach canine health and aging. It offers a glimpse into a future where our canine companions can enjoy longer, healthier lives alongside us. However, it’s crucial to balance this scientific advancement with ethical considerations to ensure the well-being of these beloved animals.

— WTF fun facts

Source: “A New Drug That Could Extend Dogs’ Lives Inches Closer to Approval” — Smithsonian Magazine

WTF Fun Fact 13081 – Dogs Fake Sneeze

Did you know that dogs fake sneeze? We know our fluffy buddies can manipulate their environment to get more attention, but fake sneezing actually has a few different uses that we found interesting.

Why do dogs fake sneeze?

According to the American Kennel Club (cited below), dogs will fake a sneeze for play and communication purposes.

“Many dogs like to sneeze when they play with other dogs or humans. This ‘play sneezing’ is normal and something dogs use to show that they are excited and having a good time. Dogs will also use play sneezing to show that their behavior is only playful.”

When dogs play sneeze, they tend to curl their lips and create a wrinkle in their nose. These sneeze sound more like a short “snort” than a sneeze, since the air comes from the nose and not the lungs.

Attention-getters

Your pup is watching you closely for signs of what will make you more empathetic and playful.

According to the AKC, “When a dog fake sneezes, they tend to watch you as they sneeze to make sure they’ve got your attention. They may even move closer and sneeze on or near you so you can’t ignore them.”

And dogs will even sneeze to communicate with one another. Sometimes, they’ll use it as a calming signal to let those around them know things are getting out of hand.

Pay attention to dog sneezes

Of course, dogs can sneeze due to illness and allergies as well. So it’s important not to assume your dog is sneezing just because it wants to play. And dogs with compressed nasal passages, like pugs, will sneeze more often simply because of their physiology. This may require attention if it starts to happen more often since it can be indicative of breathing issues. — WTF fun facts

Source: “Why Do Dogs Sneeze?” — American Kennel Club