stem cells

WTF Fun Fact 13565 – A Way To Regrow Teeth?

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Many of us grapple with tooth loss after an injury or other dental issue – so wouldn’t it be nice if, instead of paying thousands of dollars for a porcelain replacement, scientists found a way to help us regrow teeth?

Well, we’re getting closer!

Researchers from the University of Plymouth have made groundbreaking progress, unveiling a gene that may hold the secret to tooth regeneration.

The Power of Stem Cells

Historically, stem cells have been the beacon of hope in understanding and treating many diseases. That’s because they hold unparalleled potential by being capable of transforming into almost any cell type the body might need. Whether it’s forming new blood cells or rejuvenating bone cells, stem cells are invaluable in helping us recover and regenerate.

It’s no wonder, then, that scientists often harvest stem cells from youthful sources like primary teeth or wisdom teeth. Simply put, younger cells teem with vitality, making them robust candidates for regenerative medicine.

Stem cell therapy has, over the years, provided relief to patients battling conditions ranging from Alzheimer’s and diabetes to multiple sclerosis.

However, only recently have scientists honed in on how stem cells can revolutionize dental health.

Revolutionary Findings to Help Regrow Teeth

Dr. Bing Hu of the Peninsula Dental School at the University of Plymouth and his global team of scientists have uncovered a game-changing revelation: the Dlk1 gene. This gene seems to be the catalyst for enhanced stem cell activation and tissue renewal.

Their journey began with the discovery of a previously unknown group of stem cells in mouse incisors.

Typically found in muscles and bones, these mesenchymal cells spring into action when exposed to the Dlk1 gene. The result? An increased production of dentin – a crucial component in teeth.

Even more impressive was Dlk1’s ability to regenerate tissues in mice with dental injuries.

Future Implications

Of course, with all major discoveries come the caveats. Dr. Hu emphasizes the importance of further studies to cement their initial findings. Yet, he remains optimistic about transitioning from animal models to human trials soon.

This research is a beacon of hope for those who have struggled financially to have lost teeth replaced. Imagine a future where dental procedures are not only more efficient but also more affordable. A future where losing a tooth doesn’t spell permanent loss, but a temporary inconvenience.

While the Plymouth team’s findings are revolutionary, they aren’t the first to tread this path. Back in 2021, a study from Japan revealed the potential of targeting genes to regrow teeth in animals. Their focus? The USAG-1 gene. Fast forward to today, and this Japanese team is setting the stage for a 2024 clinical trial, targeting tooth regeneration in humans.

If all goes well, by 2030, we might be ushering in a new era of dental care.

—WTF fun facts

Source: “Humans Have a Third Set of Teeth. New Medicine May Help Them Grow” — Popular Mechanics and “Scientists Discover New Gene That Can Help Repair Teeth” — Today’s RDH

WTF Fun Fact 13006 – Brain Cells Learn To Play Pong

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Fun Fact: Lab-grown human and mouse brain cells living in a petri dish became sentient enough to learn to play the video game Pong.
That’s right – scientists found that brain cells learn to play Pong, the 1970s tennis-type video game.

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In news that we don’t find even remotely comforting, brain cells grown in a petri dish have been shown to become sentient enough to learn to play video games. And we’re not kidding when we say that their next plan is to get the brain cells drunk and see what happens.

Sentient brain cells living in a dish

To be clear, these are cells that are living in a petri dish – not a person. They are human cells derived from stem cells and mouse cells derived from embryonic cells. There are 800,000 cells in total involved in the experiment.

Not only have the cells learned to play the game Pong, but they keep improving. “They played longer rallies and were aced less often,” reported The Guardian (cited below). Of course, Pong is a very simple game, which is why the researchers chose it in the first place.

The study that revealed the experiment was just published in the journal Neuron.

The researchers hail from Cortical Labs, Monash University, the University of Melbourne, and University College London.

How can brain cells learn to play Pong?

According to The Guardian, the researchers out the cells on something called the “DishBrain,” “a multi-electrode array that can sense cell activity and stimulate the cells, then gave the cells feedback on whether the paddle was hitting the ball.”

Within five minutes the cells started to communicate using electrical activity to operate the game. It sounds like sci-fi, but it’s true.

“Now the researchers will see how the cells perform when they are drunk or given medicines. They hope to use the DishBrain to learn more about conditions such as epilepsy and dementia.”

“This is the new way to think about what a neuron is,” a researcher said. — WTF fun facts

Interested? See for yourself:

https://youtu.be/x0NM7iVo9MQ

Source: “Scientists teach brain cells to play video game Pong” — The Guardian

WTF Fun Fact 12986 – Healing A Broken Heart

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All you need is love. Well, all you need is oxytocin, really. That’s the brain’s “love hormone.” When it’s released into our bloodstream by our hypothalamus, it helps us bond with others and feel happy. And it turns out it could also be the key to healing a broken heart.

And we mean the real kind of broken heart – this hormone may be able to help cardiac health after a heart attack, at least according to a study using zebrafish and human cells.

Studying how to heal a broken heart

 Frontiers in Cell and Developmental Biology published the study, which found that oxytocin also has the ability to “promote the regeneration of the heart after an attack.”

According to IFL Science (cited below): “During a heart attack, cardiomyocytes – highly specialized cells responsible for heart contractions – die off. This can be a problem as they cannot replenish themselves.”

However, it appears that a subset of cells in the outer layer of the heart can undergo reprogramming and become something calls Epicardium-derived Progenitor Cells (EpiPCs). The cool thing about EpiPCs is that they can eventually become different types of heart cells, including the ones that are killed off during a heart attack.

Unfortunately, these EpiPCs need some help since they can’t regenerate fully under normal conditions. That’s why researchers looked at zebrafish.

Zebrafish are able to regrow parts of their heart. Naturally, scientists wanted to see just how they managed to do it so efficiently in the hopes that they could spur this regeneration in humans.

The role of oxytocin

The experiments involved injuring the hearts of zebrafish (through freezing them). Researchers found that the genetic material that leads to oxytocin production showed a 20-fold increase in the brain. This triggered a biological process that ended in some cells turning into EpiPCs and migrating to the heart to develop into cardiomyocytes.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” lead author Dr. Aitor Aguirre said in a news release.

Now, the question is whether we can make something similar happen in humans.

It turns out it may be possible. But we’ll have to find a way to activate the production of oxytocin in order to produce EpiPCs.  

“Oxytocin is widely used in the clinic for other reasons, so repurposing for patients after heart damage is not a long stretch of the imagination. Even if heart regeneration is only partial, the benefits for patients could be enormous,” Aguirre added.

Next steps towards healing a broken heart

Now, the team will need to look at oxytocin production in humans who have experienced cardiac injuries as well as drugs that can stimulate oxytocin production. But before working on humans, it’ll have to go through a pre-clinical trial stage.

“Next, we need to look at oxytocin in humans after cardiac injury. Oxytocin itself is short-lived in the circulation, so its effects in humans might be hindered by that. Drugs specifically designed with a longer half-life or more potency might be useful in this setting. Overall, pre-clinical trials in animals and clinical trials in humans are necessary to move forward,” Aguirre concluded. — WTF fun facts

Source: “Love Hormone” Oxytocin Could Help Mend A Broken Heart” — IFL Science