neuroscience

WTF Fun Fact 12956 – Witzelsucht, a Joke Addiction

Have you ever met anyone who couldn’t stop telling jokes, even if no one else found them funny? Maybe they had Witzelsucht.

What’s a joke addict?

In 2016, neuroscientists Elias Granadillo and Mario Mendez published a paper titled “Pathological Joking or Witzelsucht Revisited” in The Journal of Neuropsychiatry and Clinical Neurosciences that described two patients with damage to their brains suffering from joke addiction.

They explained that “impaired humor integration from right lateral frontal injury and disinhibition from orbitofrontal damage results in disinhibited humor.” Two men were used as an example.

Compulsive jokesters

According to Discover Magazine:

“Patient #1 was a 69-year-old right-handed man presented for a neuropsychiatric evaluation because of a 5-year history of compulsive joking… On interview, the patient reported feeling generally joyful, but his compulsive need to make jokes and create humor had become an issue of contention with his wife. He would  wake her up in the middle of the night bursting out in laughter, just to tell her about the jokes he had come up with. At the request of his wife, he started writing down these jokes as a way to avoid waking her. As a result, he brought to our office approximately 50 pages filled with his jokes.“

“Patient #2 was a 57-year old man, who had become “a jokester”, a transformation that had occurred gradually, over a three period. At the same time, the man became excessively forward and disinhibited, making inappropriate actions and remarks. He eventually lost his job after asking “Who the hell chose this God-awful place?” The patient constantly told jokes and couldn’t stop laughing at them. However, he did not seem to find other people’s jokes funny at all.”

Diagnosis: Witzelsucht

Apparently, both men displayed signs of something called Witzelsucht, “a German term literally meaning ‘joke addiction.'”

“Several cases have been reported in the neurological literature, often associated with damage to the right hemisphere of the brain. Witzelsucht should be distinguished from ‘pathological laughter‘, in which patients start laughing ‘out of the blue’ and the laughter is incongruent with their “mood and emotional experience.” In Witzelsucht, the laughter is genuine: patients really do find their own jokes funny, although they often fail to appreciate those of others.” — WTF fun facts

Source: “‘Joke Addiction’ As A Neurological Symptom” — Discover Magazine

WTF Fun Fact 12934 – Axolotl Brain Regeneration

In an amazing evolutionary feat that we wish were available to many of the humans we know, it turns out the salamanders known as axolotls can grow back parts of their brains. Axolotl brain regeneration is just another one of this creature’s amazing regenerative abilities.

Axolotl body regeneration

According to IFL Science (cited below), the initial discovery is an old one:

“The axolotl (Ambystoma mexicanum) is an aquatic salamander renowned for its ability to regenerate its spinal cord, heart and limbs. These amphibians also readily make new neurons throughout their lives. In 1964, researchers observed that adult axolotls could regenerate parts of their brains, even if a large section was completely removed. But one study found that axolotl brain regeneration has a limited ability to rebuild original tissue structure.”

Regenerating the brain

At the Treutlein Lab at ETH Zurich and the Tanaka Lab at the Institute of Molecular Pathology in Vienna, researchers are trying to figure out just how complete axolotl brain regeneration is. For example, one question is what types of brain cells are they able to replace?

One of the authors of a recent study noted in IFL Science that looking at brain cells was the key to understanding the regenerative process:

“In our recently published study, we created an atlas of the cells that make up a part of the axolotl brain, shedding light on both the way it regenerates and brain evolution across species. Why look at cells? Different cell types have different functions. They are able to specialize in certain roles because they each express different genes. Understanding what types of cells are in the brain and what they do helps clarify the overall picture of how the brain works. It also allows researchers to make comparisons across evolution and try to find biological trends across species.”

Axolotl brain mapping

The research team uses a specific type of RNA sequencing to get snapshots of brain samples. More specifically, they focus on the telencephalon (the region that contains the brain’s neocortex – the seat of behavior and cognition). The cells in this area are highly diversified.

By identifying the genes that are active when cells such as neurons replicate or turn into other cell types, the researchers can get a sense of how more mature cells form in the axolotl’s brain form over time.

The real test comes when the researchers inflict an injury on part of the brain, damaging some cells, then checking in later to see if they’ve regenerated.

And they found that in about 12 weeks, most of the axolotl’s brain cells have been replaced by new ones. The cells even reformed neuronal connections.

Can axolotl brain regeneration research help humans?

Even if you don’t care about axolotls, the research is important for the future of human brain research. There are many diseases that affect cognitive capacity (not to mention the role of aging on the brain). Understanding the process by which the axolotl’s brain regenerates could someday help up apply this knowledge to humans. — WTF fun facts

Source: “Axolotls Can Regenerate Their Brains – These Adorable Salamanders Are Helping Unlock The Mysteries Of Brain Evolution And Regeneration” — IFL Science

WTF Fun Fact 12820 – Do We Only Use 10% of Our Brains? No.

For some reason, Hollywood writers and purveyors of pseudoscience really love to say humans only use 10% of their brains. Why? Well, because it opens the door to making us think there’s a wealth of unlocked potential if only we could [insert Hollywood storyline] or buy some junk supplement to unlock the rest.

But it’s just not true. What an evolutionary waste that would be if it had any basis in fact!

Myth becomes “fact”

According to Britannica (and many, many scientific sources and fact-checking websites): “It’s one of Hollywood’s favorite bits of pseudoscience: human beings use only 10 percent of their brain, and awakening the remaining 90 percent—supposedly dormant—allows otherwise ordinary human beings to display extraordinary mental abilities. In Phenomenon (1996), John Travolta gains the ability to predict earthquakes and instantly learns foreign languages. Scarlett Johansson becomes a superpowered martial-arts master in Lucy (2014). And in Limitless (2011) Bradley Cooper writes a novel overnight.”

We don’t blame Hollywood – they make stuff up to sell movies all the time. It’s the fact that we started believing the plots of films that’s truly disturbing. In fact, Britannica reports that “65 percent of respondents agreed with the statement, ‘People only use 10 percent of their brain on a daily basis.'”

Yikes.

Why do we believe we only use 10% of our brains?

Let’s not look to place blame on anyone but ourselves. Most of us repeat interesting things we hear without ever investigating whether or not they’re true.

But next time you hear someone spout off this garbage “fun fact,” you can hit back with some actual science.

For starters:

  • If only 10% of our brains were functional, why does nearly every brain injury affect our lives in some way? If we only used 10%, we could damage the rest with no repercussions.
  • Why would humans have evolved our most unique characteristic – the very thing that makes us human – to be 90% useless? It makes no evolutionary sense. That space could be used for more useful things if it were just empty grey matter.
  • Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) brain scans show that there is activity in far more than 10% of our brain. In fact, there is no part of the brain that lacks some sort of electrical activity (even if we don’t yet know precisely what it does).

The origins of the 10% myth

So, the 10% myth is just complete bull. But It likely has its origins in the American self-help industry.

People like to blame 19th-century psychologist William James (or even Albert Einstein) for implying that there is unlocked potential in the human brain. And while they may be true, that doesn’t indicate inactive brain matter. It just means we could think harder if we really tried.

Britannica also states that one early claim that the self-help industry glommed onto appeared in the preface to Dale Carnegie’s 1936 book, How to Win Friends and Influence People. Since then, “The idea that we have harnessed only a fraction of our brain’s full potential has been a staple for motivational gurus, New Age hucksters, and uninspired screenwriters ever since.”

But it’s a load of bologna. – WTF fun facts

Source: “Do We Really Use Only 10 Percent of Our Brain?” — Britannica

WTF Fun Fact 12403 – Your Brain on Math

Mathematics is a strange beast. It uses our language, but it isn’t quite the same – our brains hear it entirely differently from everyday speech. For example: when we hear a sentence like “cats like warm milk,” our brains process that information mainly in the left hemisphere. Something like “eight plus one is nine,” though, will fire neurons in both.

A study published in the journal Current Biology took a closer look at how our brains process mathematics (as opposed to regular speech). While our brains process ordinary language in the left hemisphere, math triggers neurons in both hemispheres.

The neuroscientists from the Universities of Tübingen and Bonn said in an interview: “We found that different neurons fired during additions than during subtractions.”

Esther Kutter, a doctoral candidate involved with the research group, confirmed: “Even when we replaced the mathematical symbols with words, the effect remained the same. For example, when subjects were asked to calculate ‘5 and 3’, their addition neurons sprang back into action; whereas for ‘7 less 4,’ their subtraction neurons did.”

The lead author of the study Prof. Dr. Dr. Florian Mormann of the Department of Epileptology at University Hospital Bonn, remarked on the study’s significance: “This study marks an important step towards a better understanding of one of our most important symbolic abilities, namely calculating with numbers.” – WTF Fun Facts

Source: Math Neurons” Fire Differently Depending On Whether You Add Or Subtract — IFL Science